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D+ in mathematics is a big problem? Are you looking for a course in business, education, languages, or agriculture?
With that performance in Mathematics, options are very limited. You might want to consider religious studies courses in colleges or Artisan courses offered in TVET institutions.
There are a number of diploma courses that you can apply for with KCSE grade (C-). Kindly visit https://students.kuccps.net/programmes/, under diploma programmes, check for course that you might be interested in.
There are hundreds of courses that you can do in University with KCSE grade B- or D+ in Mathematics. What are your career interests so that we can provide you with suggestions?
You can apply for any diploma medicine related courses offered in KMTC. For instance, Clinical Medicine, Medical Laboratory sciences, Radiography and Imaging, Pharmacy, etc. However, you must have C (plain) in Physics since they require C (plain) in either Maths or Physics. Here is a complete list of all the courses offered in KMTC and their requirements: https://kmtc.ac.ke/wp-content/uploads/2020/02/KMTC-Programmes-Courses-Feb-2020.pdf Alternatively, consider doing any degree course that is not related to medicine and which Maths is not a requirement.